Recurrent breast cancer

Can Locoregionally Recurrent Breast Cancer Be Cured?

Locoregional recurrence (LRR) of breast cancer can occur after multidisciplinary treatment of a primary breast cancer. With modern multidisciplinary breast cancer treatment, the incidence of isolated LRR is decreasing. Improvements in systemic therapy are driving the decrease in LRR. LRR does still occur, however. LRR reflects biology of the cancer, as does systemic recurrence. LRR of breast ca...

Multidrug resistance protein in recurrent breast cancer.

1885 remained otherwise well until January, 1996, when he developed recurrent biliary stricturing with jaundice and worsening diarrhoea. Trough cyclosporin concentrations were considered sub-therapeutic at 60 ng/mL and so he was converted to Neoral therapy at the same dose. Several 12-h trough whole blood cyclosporin levels were taken over the following 2 months, and did not exceed 125 ng/mL. I...

Radiation Therapy for Locally Recurrent Breast Cancer

Approximately one-third of all breast cancer patients experience local recurrence of their tumor after initial treatment. As initial treatment often employs the use of radiation therapy (RT), the standard of care for local breast cancer recurrence after initial breast conserving therapy has traditionally been surgical intervention with mastectomy. However, recent attempts to preserve the intact...

Breast Implants and Breast Cancer

Re-irradiation for locally recurrent refractory breast cancer

PURPOSE To report an analysis of treatment outcomes of a cohort of patients re-irradiated for locally recurrent refractory breast cancer (LRRBC). PATIENTS AND METHODS Between 2008 and 2013, 47 women (mean age = 60 years) were re-irradiated for LRRBC. Outcomes were measured using Kaplan-Meier log rank to compare curves and Cox regression for multivariate analysis. Outcomes included overall sur...